Omeprazole
Gastrointestinal
Proton pump inhibitor for acid-related disorders.
Generic name: Omeprazole
Brand names: Losec, Prilosec, Omez, Lomac
Dosage
Adults: 20 mg once daily before breakfast for 4–8 weeks; double-dose in H. pylori triple therapy.
Side effects
Headache, diarrhea, abdominal pain. Long-term use linked to low magnesium, B12 deficiency, and increased fracture risk.
Contraindications
Concomitant clopidogrel (reduced effect); known hypersensitivity to PPIs.
Description
Omeprazole blocks the H+/K+-ATPase in gastric parietal cells, reducing acid secretion. Used for GERD, peptic ulcer disease, Zollinger–Ellison syndrome, and H. pylori eradication regimens.