Atorvastatin

Adults: 10–40 mg once daily, taken at any time of day. 80 mg for high-intensity therapy.

Myalgia, raised liver enzymes, slight increase in new-onset diabetes risk. Rare: rhabdomyolysis.

Active liver disease, pregnancy, breastfeeding, concomitant strong CYP3A4 inhibitors.

Atorvastatin inhibits HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis. Lowers LDL-C by 30–55 % at typical doses; reduces major adverse cardiovascular events in primary and secondary prevention.