Amlodipine

Adults: 5 mg once daily, may increase to 10 mg after 1–2 weeks.

Peripheral oedema (especially ankles), flushing, headache, dizziness.

Cardiogenic shock, severe aortic stenosis, unstable angina, severe hepatic impairment.

Amlodipine is a long-acting dihydropyridine that relaxes vascular smooth muscle, lowering blood pressure and reducing afterload. First-line in hypertension and chronic stable angina. Once-daily dosing with a slow onset and offset.